年度报告摘要

云南省公共卫生与生物安全重点实验室依托昆明医科大学建设,主任为夏雪山教授,具体由公共卫生学院、基础医学院、云南省疾病预防控制中心和昆明理工大学联合共建,旨在提升云南省公共卫生与生物安全领域的基础研究、技术开发和推广应用水平。

获批建设至今的短短几个月时间,实验室人员齐心协力,克服时间短、任务重的重重困难,让实验室运行步入正轨。实验室围绕影响人民健康的病原生物、环境、食品等主要因素,集成公共卫生—预防医学—基础医学学科专业优势,聚焦公共卫生尤其是重大传染病面临的防控核心问题,加大基础研究和研究成果转化应用,加大生物安全危害因素分析与防控技术研究,形成传染病学、流行病统计学、病原生物学、环境与职业健康、食品安全及生物安全五个研究方向。

2023年,实验室人员成绩斐然!夏雪山教授领衔主持的国家重点研发计划“病原学与防疫技术体系研究”重点专项2023年度项目立项,实现了昆明医科大学国家重点专项零的突破;董兴齐,夏雪山教授等主持的“云南省HIV/AIDS抗病毒治疗耐药监测技术体系构建及其在精准治疗中的应用” 项目获得2023年度云南省科学技术进步一等奖;柳爱华、宝福凯教授主持的“宿主免疫控制结核病进程的机制和实时监测技术研究”项目获2023年云南省自然科学奖二等奖;据不完全统计,2023年实验室成员共发表SCI文章70篇(附后)。这是公共卫生与生物安全重点实验室自主创新、辛勤耕耘的硕果,更是实验室蓬勃发展,红红火火,大力发展的好兆头!

时光荏苒,转眼即将走过2023。值此辞旧迎新之际,相信实验室全体成员将不断开拓进取、攻坚克难,扩大影响力、建设新水平,在新的一年为公共卫生与生物安全重点实验室的发展和建设作出更大贡献!


附实验室2023年发表SCI文章(70篇): 

1.传染病与生物安全技术方向(22):

Mahmood F, Xu R, Awan MUN, Song Y, Han Q, Xia X, Wei J, Xu J, Peng J, Zhang J. HBV Vaccines: Advances and Development. Vaccines (Basel). 2023 Dec 18;11(12):1862.

Fan Y, Hou Y, Li Q, Dian Z, Wang B, Xia X. RNA virus diversity in rodents. Arch Microbiol. 2023 Dec 1;206(1):9.

Shah T, Hou Y, Jiang J, Shah Z, Wang Y, Li Q, Xu X, Wang Y, Wang B, Xia X. Comparative analysis of the intestinal microbiome in Rattus norvegicus from different geographies. Front Microbiol. 2023 Nov 3;14:1283453.

Zou Y, Yue M, Jia L, Wang Y, Chen H, Zhang A, Xia X, Liu W, Yu R, Yang S, Huang P. Accurate prediction of HCC risk after SVR in patients with hepatitis C cirrhosis based on longitudinal data. BMC Cancer. 2023 Nov 25;23(1):1147.

Ding Y, Gao Y, Chen R, Zhang Z, Li Q, Jia T, Zhang T, Xu R, Shi W, Chen L, Song Y, Han Q, Xia X, Song J, Zhang J. Development of a novel multi-epitope oral DNA vaccine for rabies based on a food-borne microbial vector. Int J Biol Macromol. 2023 Nov 15;255:128085.

Liu L, Li M, Liu G, He J, Liu Y, Chen X, Tu Y, Lin J, Feng Y, Xia X. A novel, highly sensitive, one-tube nested quantitative real-time PCR for Brucella in human blood samples. Microbiol Spectr. 2023 Dec 12;11(6):e0058223.

Liu M, Zhao T, Zhang Y, Zhang AM, Geng J, Xia X. The incidence of hepatocellular carcinoma and clearance of hepatitis B surface for CHB patients in the indeterminate phase: a systematic review and meta-analysis. Front Cell Infect Microbiol. 2023 Sep 12;13:1226755.

Shah T, Wang Y, Wang Y, Li Q, Zhou J, Hou Y, Wang B, Xia X. A Comparative Analysis of the Stomach, Gut, and Lung Microbiomes in Rattus norvegicus. Microorganisms. 2023 Sep 21;11(9):2359.

Zhang Y, Feng Y, Liu Y, Liu L, Xia X, Zhang AM. Genetic polymorphisms in the C19orf66 gene influenced HIV-1 infection in a Yunnan population. Peer J. 2023 Sep 7;11:e16005.

Zhou H, Xie P, Qiu M, Dong S, Xia X, Yang Z, Yuan Y, Shen L. Arbidol increases the survival rate by mitigating inflammation in suckling mice infected with human coronavirus OC43 virus. J Med Virol. 2023 Sep;95(9):e29052.

Jia Y, Zou X, Yue W, Liu J, Yue M, Liu Y, Liu L, Huang P, Feng Y, Xia X. The distribution of hepatitis C viral genotypes shifted among chronic hepatitis C patients in Yunnan, China, between 2008-2018. Front Cell Infect Microbiol. 2023 Jul 11;13:1092936.

Shah T, Li Q, Wang B, Baloch Z, Xia X. Geographical distribution and pathogenesis of ticks and tick-borne viral diseases. Front Microbiol. 2023 May 24;14:1185829.

Liu N, Liu M, Yang J, Dong S, Yue M, Huang P, Xia X, Zhang AM. Association of genetic polymorphisms in the C19orf66 gene and biochemical indices of HBV infected individuals in Yunnan. Front Cell Infect Microbiol. 2023 May 24;13:1180366.

Mahmood F, Xu R, Awan MUN, Jia T, Zhang T, Shi W, Liu M, Han Q, Zhu Q, Zhang Q, Song Y, Xia X, Zhang J. Transcriptomics based identification of S100A3 as the key anti-hepatitis B virus factor of 16F16. Biomed Pharmacother. 2023 Jul;163:114904.

Qu L, Li X, Huang B, Liu Y, Li Q, Shah T, Ning Y, Li J, Lu Y, Yan L, Wang B, Xia X. Identification and Characterization of Jingmen Tick Virus in Ticks from Yunnan Imported Cattle. Vector Borne Zoonotic Dis. 2023 May;23(5):298-302.

Liu J, Li J, Wang B, Liu Y, Liu L, Liu Y, Feng Y, Qin W, Xia X. Characterization of a newly emerging HCV subtype 6xk among Burmese travelers arriving at Ruili Port in Yunnan, China. J Infect. 2023 Jul;87(1):72-75.

Zhang L, Ye X, Liu Y, Zhang Z, Xia X, Dong S. Research progress on the effect of traditional Chinese medicine on the activation of PRRs-mediated NF-κB signaling pathway to inhibit influenza pneumonia. Front Pharmacol. 2023 Apr 7;14:1132388.

Wu X, Li RF, Lin ZS, Xiao C, Liu B, Mai KL, Zhou HX, Zeng DY, Cheng S, Weng YC, Zhao J, Chen RF, Jiang HM, Chen LP, Deng LZ, Xie PF, Yang WM, Xia XS, Yang ZF. Coinfection with influenza virus and non-typeable Haemophilus influenzae aggregates inflammatory lung injury and alters gut microbiota in COPD mice. Front Microbiol. 2023 Mar 30;14:1137369.

Feng Z, Huang P, Zhang J, Xia X, Zhang AM, Zeng T, Chen Q, Zhu C, Tan W, Zhang Y, Yue M. KIR2DL4/HLA-G polymorphisms were associated with HCV infection susceptibility among Chinese high-risk population. J Med Virol. 2023 Mar;95(3):e28645.

He M, Liu M, Geng J, Liu L, Huang P, Yue M, Xia X, Zhang AM. Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients. Front Cell Infect Microbiol. 2023 Jan 19;13:1119805.

Li Q, Shah T, Wang B, Qu L, Wang R, Hou Y, Baloch Z, Xia X. Cross-species transmission, evolution and zoonotic potential of coronaviruses. Front Cell Infect Microbiol. 2023 Jan 6;12:1081370.

Xu X, Luo Y, He C, Dian Z, Mi H, Yang J, Feng Y, Miao Z, Xia X. Increased Risk of Neurological Disease Following Pediatric Rotavirus Infection: A Two-Center Case-Control Study. J Infect Dis. 2023 May 29;227(11):1313-1321.

2. 环境与职业健康方向(4):

Xu J, Wang J, He Y, Chen R, Meng Q. L.acidophilus participates in intestinal inflammation induced by PM2.5 through affecting the Treg/Th17 balance. Environ Pollut. 2023 Nov 23;341:122977.

Chen Q, Sun M, Cheng H, Qi J, Tan J, Gu Y, Yu T, Li M, Xu H, He Y, Wen W. Inorganic arsenic-mediated upregulation of TUG1 promotes apoptosis in human bronchial epithelial cells by activating the p53 signaling pathway. Toxicol Ind Health. 2023 Dec;39(12):700-711.

Yu J, Li S, Shen S, Zhou Q, Yin J, Zhao R, Tan J, Jiang C, He Y. The transcript NR 134251.1 of lncRNA APTR with an opposite function to all transcripts inhibits proliferation and induces apoptosis by regulating proliferation and apoptosis-related genes. Hum Exp Toxicol. 2023 Jan-Dec;42:9603271221150247.

Sun M, Cheng H, Yu T, Tan J, Li M, Chen Q, Gu Y, Jiang C, Li S, He Y, Wen W. Involvement of a AS3MT/c-Fos/p53 signaling axis in arsenic-induced tumor in human lung cells. Environ Toxicol. 2023 Mar;38(3):615-627.

3. 流行病统计学方向(14):

Zhang M, Li J, Fan J, Feng D, Li Q, Tang S, Li J. Cross-border Activities Associated With Pattern of Amphetamine-type Stimulants Usage Among Drug Users in Southwest of China. Inquiry. 2023 Jan-Dec;60:469580231206608.

Fan L, Liu L, Zhao Y, Mo Y, Li J, Cai L. Trends in the prevalence and economic burden of hypertension and its socioeconomic disparities in rural southwestern China: two repeated cross-sectional studies. BMJ Open. 2023 Nov 17;13(11):e076694.

Du YR, Liu L, Zhao Y, Huang JJ, Golden AR, Cai L. Ethnic disparities in prevalence of chronic non-communicable diseases and its multimorbidity among older adults in rural southwest China. BMC Public Health. 2023 Jun 23;23(1):1217.

Zhao M, Pu X, Ma GY, Zhang MJ, Luo L, Gu RY, Gao MZ, Cai L. Quality of life in patients with cervical cancer between the Han nationality and ethnic minorities in the Yunnan Province of China. BMC Womens Health. 2023 May 3;23(1):217.

Le C, Liu L, Li GH, Zhao Y, Wu X, Rabkin Golden A. Trends in prevalence and clustering of modifiable cardiovascular disease risk factors across socioeconomic spectra in rural southwest China: a cross-sectional study. BMJ Open. 2023 Apr 27;13(4):e071152.

Zhao Y, Li HF, Wu X, Li GH, Golden AR, Cai L. Rural-urban differentials of prevalence and lifestyle determinants of pre-diabetes and diabetes among the elderly in southwest China. BMC Public Health. 2023 Mar 30;23(1):603.

Cai L, Wang XM, Liu L, Zhao Y, Golden AR. Socioeconomic differentials of trends in the prevalence and economic burden of chronic obstructive pulmonary disease in rural southwest China. BMC Public Health. 2023 Jan 20;23(1):141.

Liu M, Yan G, Li Y, You R, Liu L, Zhang D, Yang G, Dong X, Ding Y, Yan S, You D, Li Z. Preoperative splenic area as a prognostic biomarker of early-stage non-small cell lung cancer. Cancer Imaging. 2023 Dec 1;23(1):116.

You D, Wang Y, Xu J, Yang R, Wang W, Wang X, Cao X, Li Y, Yu L, Wang W, Shi Y, Zhang C, Yang H, He Y, Bian L. MiR-3529-3p from PDGF-BB-induced cancer-associated fibroblast-derived exosomes promotes the malignancy of oral squamous cell carcinoma. Discov Oncol. 2023 Sep 5;14(1):166.

Wang WZ, Cao X, Bian L, Gao Y, Yu M, Li YT, Xu JG, Wang YH, Yang HF, You DY, He YW. Analysis of mRNA-miRNA interaction network reveals the role of CAFs-derived exosomes in the immune regulation of oral squamous cell carcinoma. BMC Cancer. 2023 Jun 26;23(1):591.

Luo J, Tang L, Zhang R, Lv M, You D, Yuan Q. Transcriptome-wide profile of 1α,25 dihydroxyvitamin D3 in HTR-8/SVneo cells. J Obstet Gynaecol Res. 2023 Aug;49(8):2093-2101.

Liu W, Luo Z, Zhang L, Wang Y, Yang J, You D, Cao X, Yang W. hsa-mir-(4328, 4422, 548z and -628-5p) in diabetic retinopathy: diagnosis, prediction and linking a new therapeutic target. Acta Diabetol. 2023 Jul;60(7):929-942.

Li C, Zhao K, Zhang D, Pang X, Pu H, Lei M, Fan B, Lv J, You D, Li Z, Zhang T. Prediction models of colorectal cancer prognosis incorporating perioperative longitudinal serum tumor markers: a retrospective longitudinal cohort study. BMC Med. 2023 Feb 21;21(1):63.

Zhang Y, Luo MT, Wu Q, Wang YX, Ma X, Yan G, Zhang SH, Chen Y, Wan N, Zhang L, You D, Wei J, Zhang Z, Zhou TC; Precise-CoVaccine study group. Long-term and effective neutralization against omicron sublineages elicited by four platform COVID-19 vaccines as a booster dose. Cell Discov. 2023 Feb 8;9(1):17.

4. 病原生物学方向(12):

Xu X, Wen S, Zhang Y, Cao W, Yue P, Kong J, Liu M, Fan Y, Chen J, Ji Z, Dong Y, Zhou G, Li B, Liu A, Bao F. A key protein from Borrelia burgdorferi could stimulate cytokines in human microglial cells and inhibitory effects of Cucurbitacin IIa. IBRO Neurosci Rep. 2023 Nov 13;15:376-385.

Ma W, Liu A, Wu X, Gao L, Chen J, Wu H, Liu M, Fan Y, Peng L, Yang J, Kong J, Li B, Ji Z, Dong Y, Luo S, Song J, Bao F. The intricate role of CCL5/CCR5 axis in Alzheimer disease. J Neuropathol Exp Neurol. 2023 Oct 20;82(11):894-900.

Yang J, Kong J, Li B, Ji Z, Liu A, Chen J, Liu M, Fan Y, Peng L, Song J, Wu X, Gao L, Ma W, Dong Y, Luo S, Bao F. Seventy years of evidence on the efficacy and safety of drugs for treating leprosy: a network meta-analysis. J Infect. 2023 Apr;86(4):338-351.

Chen J, Gao L, Wu X, Fan Y, Liu M, Peng L, Song J, Li B, Liu A, Bao F. BCG-induced trained immunity: history, mechanisms and potential applications. J Transl Med. 2023 Feb 10;21(1):106.

Zhang X, Jiang Y, Chen Y, Yang J, Zhang X, Xing L, Liu A, Bao F. Efficacy and safety of antibiotic therapy for post-Lyme disease? A systematic review and network meta-analysis. BMC Infect Dis. 2023 Jan 12;23(1):22.

Wang E, Huang X, Ye Y, Zou S, Chen G, Yang L, Fraser NW, Bao F, Zhou J, Cao X. Persistent inflammation and neuronal loss in the mouse brain induced by a modified form of attenuated herpes simplex virus type I. Virol Sin. 2023 Feb;38(1):108-118.

Wu Y, Ran L, Yang Y, Gao X, Peng M, Liu S, Sun L, Wan J, Wang Y, Yang K, Yin M, Chunyu W. Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota. Life Sci. 2023 Feb 1;314:121312.

Malla P, Wang Z, Brashear A, Yang Z, Lo E, Baird K, Wang C, Cui L. Effectiveness of unsupervised primaquine regimen for preventing Plasmodium vivax malaria relapses in northeast Myanmar, a single-arm non-randomized observational study. J Infect Dis. 2023 Dec 2:jiad552.

Chen X, Tao Z, Liang Y, Ma M, Adah D, Ding W, Chen L, Li X, Dai L, Fanuel S, Zhao S, Hu W, Wu D, Duan Z, Zhou F, Qin L, Chen X, Yang Z. Plasmodium immunotherapy combined with gemcitabine has a synergistic inhibitory effect on tumor growth and metastasis in murine Lewis lung cancer models. Front Oncol. 2023 Oct 17;13:1181176.

Xiang Z, Li D, Wang S, Shen T, He W, Li M, Zeng W, Chen X, Wu Y, Cui L, Yang Z. A simple alkali lysis method for Plasmodium falciparum DNA extraction from filter paper blood samples. Mol Biochem Parasitol. 2023 Jun;254:111557.

Wang X, Bai Y, Xiang Z, Zeng W, Wu Y, Zhao H, Zhao W, Chen X, Duan M, Li X, Zhu W, Sun K, Wu Y, Zhang Y, Li X, Rosenthal BM, Cui L, Yang Z. Genetic diversity of Plasmodium vivax populations from the China-Myanmar border identified by genotyping merozoite surface protein markers. Trop Med Health. 2023 Jan 11;51(1):2.

Duan M, Bai Y, Deng S, Ruan Y, Zeng W, Li X, Wang X, Zhao W, Zhao H, Sun K, Zhu W, Wu Y, Miao J, Kyaw MP, Yang Z, Cui L. Different In Vitro Drug Susceptibility Profile of Plasmodium falciparum Isolates from Two Adjacent Areas of Northeast Myanmar and Molecular Markers for Drug Resistance. Trop Med Infect Dis. 2022 Dec 17;7(12):442.

5. 食品安全方向(14):

Hou Z, Chen Y, Sun Y, Song C, Deng H, Cheng N, Han X, Zhang J, Wang Q, Li Y, Yin J, Meng Q. Sleep Duration and Insomnia with Comorbid Depression and Anxiety Symptoms in Chinese Adults: A Cross-Sectional Study. Nat Sci Sleep. 2023 Dec 21;15:1079-1091.

Xiang Y, Xu H, Chen H, Tang D, Huang Z, Zhang Y, Wang Z, Wang Z, Yangla, Han M, Yin J, Xiao X, Zhao X. Tea consumption and attenuation of biological aging: a longitudinal analysis from two cohort studies. Lancet Reg Health West Pac. 2023 Nov 22;42:100955.

Sun Y, Han X, Hou Z, Deng H, Cheng N, Zhang N, Zhang J, Li Y, Wang Q, Yin J, Meng Q. Association between leisure sedentary behaviour and uterine fibroids in non-menopausal women: a population-based study. BMJ Open. 2023 Nov 28;13(12):e073592.

Zhang T, Li M, Zhao Z, Hong R, Wang X, Yin J. Effective support and care in community: The "Nine to One" comprehensive support mode of people living with Schizophrenia in less-developed multiethnic region of Southwest China. Asian J Psychiatr. 2023 Dec;90:103833.

Guo B, Huang S, Li S, Han X, Lin H, Li Y, Qin Z, Jiang X, Wang Z, Pan Y, Zhang J, Yin J, Zhao X; China Multi-Ethnic Cohort (CMEC) collaborative group. Long-term exposure to ambient PM2.5 and its constituents is associated with MAFLD. JHEP Rep. 2023 Sep 17;5(12):100912.

Li K, Yin J, Qin Z, Ma B, He R, Zhuoma D, Wang Z, Liu Q, Zhao X. Age at menarche and metabolic dysfunction-associated fatty liver disease: Evidence from a large population-based epidemiological study in Southwest China. Prev Med. 2023 Dec;177:107776.

Deng H, Zhang X, Cheng N, Zhang J, Song C, Sun Y, Hou Z, Li Y, Wang Q, Yin J, Meng Q. Asymptomatic hyperuricemia associated with increased risk of nephrolithiasis: a cross-sectional study. BMC Public Health. 2023 Aug 10;23(1):1525.

Qian Y, Che Z, Fu C, Chen X, Zeng J, Zhang X, Zeng Y, Yin J. Study on the Association Between Dietary Quality and Overweight/Obesity of Han Nationality with Cold in Yunnan Plateau by DBI-16 - A Study Based on a Multi-Ethnic Cohort in China. Diabetes Metab Syndr Obes. 2023 Aug 3;16:2311-2327.

Zhao Z, Huang J, Zhong D, Wang Y, Che Z, Xu Y, Hong R, Qian Y, Meng Q, Yin J. Associations of three thermogenic adipokines with metabolic syndrome in obese and non-obese populations from the China plateau: the China Multi-Ethnic Cohort. BMJ Open. 2023 Jul 25;13(7):e066789.

Zhou J, He R, Shen Z, Zhang Y, Gao X, Dejiquzong, Xiao X, Zhang T, Yang D, Wang Y, Song H, Guo Y, Li S, Chen G, Yin J, Zhao X; China Multi-Ethnic Cohort (CMEC) collaborative group. Altitude and metabolic syndrome in China: Beneficial effects of healthy diet and physical activity. J Glob Health. 2023 Jun 30;13:04061.

Zhao Y, Liang X, Wang J, Baima K, Nima Q, Gao Y, Yin J, Liu Q, Zhao X. Association between pregnancy termination history and metabolic syndrome in southwestern Chinese women: modification effect of physical activity. Hum Reprod. 2023 Aug 1;38(8):1560-1570.

Chen J, Zuo H, Wu X, Zhang Y, Tan Q, Yu Z, Laba C, Pan Y, Yin J, Hong F, Zeng P, Zhao X. Diverse associations between adiposity and blood pressure among 80,000 multi-ethnic Chinese adults. BMC Public Health. 2023 Feb 9;23(1):298.

Wu X, Tang W, Tang D, Hu Y, Zhang N, Dai S, Pan Y, Li J, Guan H, Meng J, Zhao X, Xiao X, Yin J. Two a posteriori dietary patterns are associated with risks of hyperuricemia among adults in less-developed multiethnic regions in Southwest China. Nutr Res. 2023 Feb;110:96-107.

Li S, Guo B, Jiang Y, Wang X, Chen L, Wang X, Chen T, Yang L, Silang Y, Hong F, Yin J, Lin H, Zhao X. Long-term Exposure to Ambient PM2.5 and Its Components Associated With Diabetes: Evidence From a Large Population-Based Cohort From China. Diabetes Care. 2023 Jan 1;46(1):111-119.

6. 生物安全防护方向(2):

Cao R, Lei S, Chen H, Ma Y, Dai J, Dong L, Jin X, Yang M, Sun P, Wang Y, Zhang Y, Jia M, Chen M. Using molecular network analysis to understand current HIV-1 transmission characteristics in an inland area of Yunnan, China. Epidemiol Infect. 2023 Jul 18;151:e124.

Chen M, Ma Y, Chen H, Lei S, Jia M. Identification of a new HIV-1 second-generation circulating recombinant form (CRF134_0185) in Yunnan, China. J Infect. 2023 Jul;87(1):e12-e15.

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