廖玉辉，国家优青，国家重点研发计划首席科学家，广东省杰青，昆明医科大学高层次人才(第二层次：领军人才)、医工交叉研究院院长、科技处处长。研究团队围绕高灵敏度功能探针构建及重大疾病标志物的定量分析开展研究，建立了病灶特异的功能探针，实现了重大传染病诊断、治疗新策略(Nature Nanotechnology, IF=38.3; Advanced Materials 2篇, IF=29.4; Matter, IF=18.9; Aggregate 2篇, IF= 18.8; ACS Nano 2篇, IF=17.1)；设计了信号放大探针，实现了传染病病原体实时监测及普适性标志物检测(Nature Protocols, IF=14.8; ACS Central Science, IF=18.2; Theranostics, IF=12.4; ACS Nano, IF=17.1)；构建了靶标触发的功能探针，应用于病灶在体成像诊断及高灵敏度液体活检新模式(Advanced Materials 2篇, IF=29.4; Bioactive Materials, IF=18.9; Angewandte Chemie, IF= 16.6; Small 2篇, IF=13.3; Redox Biology, IF=11.4; Journal of Controlled Release, IF=10.8)。已发表论文40篇，其中IF>10的19篇，ESI热点论文4篇，ESI高被引论文9篇，SCI一区论文30篇，他引1000次以上，单篇引用最高155次，H指数为24，i10指数为34；主持国家重点研发计划1项，国家自然科学基金项目4项，广东省自然科学基金杰出青年项目1项，申请国家发明专利30项、授权12项。任中国中西医学会传染病专业委员会青年委员，中国检验装备学会检验医学分会委员，广东省青年科学家协会会员，广东省医学会放射医学分会分子影像学组委员，广东省精准医学应用学会长青人智库委员会委员。可招收相关专业的硕博研究生。
电子邮箱：liaoyh8@mail.sysu.edu.cn
个人简历：
2024年5月-至今 昆明医科大学高层次人才(第二层次：领军人才)医工交叉研究院院长 科技处处长
2019年4月-2024年4月 南方医科大学高层次人才(优秀青年学者)研究员
2017年6月-2018年11月 中山大学 中山医学院 免疫学教研室 诊断组负责人 特聘副研究员
2016年7月-2017年1月 华南师范大学 生物光子学研究院 师资博士后
2011年9月-2016年6月 华南师范大学 生物光子学研究院 博士
2010年7月-2011年8月 中国科学院 昆明植物研究所 技术员
2006年9月-2010年6月 西南科技大学 生命科学与工程学院 学士
主要项目：
1)国家重点研发计划，青年科学家项目，2022-01至2024-12，1300万元，在研，主持；
2)国家自然科学基金委员会，优秀青年科学基金项目，2024-01至2026-12,200万元，在研，主持；
3)广东省基础与应用基础研究基金自然科学基金，杰出青年项目,2022-01至2025-12，150万元，在研，主持；
4)国家自然科学基金委员会，面上项目，2023-01至2026/12，52万元，在研，主持；
5) 国家自然科学基金委员会，面上项目，2020-01至2023/12，55万元，在研，主持；
6) 国家自然科学基金委员会，青年科学基金项目，2020-01至2022-12，24.5万元，结题，主持。
近期代表性成果：
2024年
1. Fu Y, Chen X, Song W, et al. Light-Switch Electrochemiluminescence-Driven microfluidic sensor for rapid and sensitive detection of Mpox virus[J]. Chemical Engineering Journal, 2024, 498: 154930.
2. Yang H, Zheng J, Wang W, et al. Zr-MOF carrier-enhanced dual-mode biosensing platforms for rapid and sensitive diagnosis of mpox[J]. Advanced Science, 2024, 11(38): 2405848.
3. Yang Z, Su J, Wang J, et al. Spin-coating fabrication of high‐yield and uniform organic thin‐film transistors via a primer template growth[J]. Aggregate, 2024: e661.
4. Wang H, Li B, Sun Y, et al. NIR‐II AIE Luminogen‐Based Erythrocyte-Like Nanoparticles with Granuloma‐Targeting and Self‐Oxygenation Characteristics for Combined Phototherapy of Tuberculosis[J]. Advanced Materials, 2024, 36(38): 2406143.
5. Zhao M, Kang M, Wang J, et al. Stem Cell‐Derived Nanovesicles Embedded in Dual‐Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing[J]. Advanced Materials, 2024: 2401369.
6. Wang W, Li B, Wu Y, et al. Macrophage-derived biomimetic nanoparticles for light-driven theranostics toward Mpox[J]. Matter, 2024, 7(3): 1187-1206.
7. Guan H, Wang W, Jiang Z, et al. Magnetic Aggregation-Induced Bone-Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic–Angiogenic Coupling for Osteoporotic Bone Repair[J]. Advanced Materials, 2024, 36(13): 2312081.
8. Li B, Wang W, Zhao L, et al. Aggregation‐induced emission-based macrophage‐like nanoparticles for targeted photothermal therapy and virus transmission blockage in Monkeypox[J]. Advanced Materials, 2024, 36(9): 2305378.
9. Li B, Wang W, Zhao L, et al. Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles[J]. Nature Nanotechnology, 2024: 1-12.
10. Chen X, Zhao M, Xie Q, et al. Click‐hydrogel delivered aggregation‐induced emissive nanovesicles for simultaneous remodeling and antibiosis of deep burn wounds[J]. Aggregate, 2024, 5(1): e406.
11. Wu T, Fu Y, Guo S, et al. Self-assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic-resistant bacteria[J]. Aggregate, 2024, 5(1): e402.
12. Zheng J, Chen T, Wang K, et al. Engineered multifunctional zinc-organic framework-based aggregation-induced emission nanozyme for accelerating spinal cord injury recovery[J]. ACS nano, 2024, 18(3): 2355-2369.
13. Wang W, Wang J, Hu Z, et al. Advancing Aggregation‐Induced Emission‐Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases[J]. Aggregate, 2024: e715.
14. Li X, Wang W, Gao Q, et al. Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging‐guided photodynamic therapy of drug-resistant superbug infections and burn wound healing[C]//Exploration. 2024: 20230113.
15. Lin W, Shen C, Li M, et al. Programmable Macrophage Vesicle Based Bionic Self‐Adjuvanting Vaccine for Immunization against Monkeypox Virus[J]. Advanced Science, 2024: 2408608.
16. Fan Z, Liu Y, Ye Y, et al. Functional probes for the diagnosis and treatment of infectious diseases[J]. Aggregate, 2024: e620.
17. Zhang D, Tian B, Ling Y, et al. CRISPR/Cas12a-Powered Amplification-Free RNA Diagnostics by Integrating T7 Exonuclease-Assisted Target Recycling and Split G-Quadruplex Catalytic Signal Output[J]. Analytical Chemistry, 2024.
2023年
1. Ji Z, Zheng J, Ma Y, et al. Emergency Treatment and Photoacoustic Assessment of Spinal Cord Injury Using Reversible Dual-Signal Transform-Based Selenium Antioxidant. Small. 2023;19(35):e2207888.
2. Guan H, Wang W, Jiang Z, et al. Magnetic Aggregation-Induced Bone-Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic-Angiogenic Coupling for Osteoporotic Bone Repair. Adv Mater. 2024;36(13):e2312081.
3. Li B, Wang W, Zhao L, et al. Multifunctional AIE Nanosphere-Based "Nanobomb" for Trimodal Imaging-Guided Photothermal/Photodynamic/Pharmacological Therapy of Drug-Resistant Bacterial Infections.ACS Nano. 2023;17(5):4601-4618.
4. Wu T , Fu Y , Guo S ,et al.Self‐assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic‐resistant bacteria[J].Aggregate, 2024, 5(1): e402
5. Wu T, Wang H, Tian R, et al. A DNA Origami-based Bactericide for Efficient Healing of Infected Wounds. Angew Chem Int Ed Engl. 2023;62(46):e202311698.
6. Lin W, Huang J, Guo S, et al. A tunable fluorescent probe for superoxide anion detection during inflammation caused by Treponema pallidum. J Mater Chem B. 2023;11(20):4523-4528.
7. Fu Y, Zeng L, Huang P, et al. Severity-onset prediction of COVID-19 via artificial-intelligence analysis of multivariate factors. Heliyon. 2023;9(8):e18764.
8. Peng C, Luo J, Wang K, et al. Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species. Redox Biol. 2023;67:102913.
9. Huang J, Jiang Y, Lin W, et al. Virulence and Adhesion of the Treponema pallidumNichols Strain Simultaneously Decrease in a Continuous-Infection New Zealand White Rabbit Model. ACS Infect Dis. 2023;9(6):1221-1231.
10. Fu Y, Liu Y, Song W, et al. Early monitoring-to-warning Internet of Things system for emerging infectious diseases via networking of light-triggered point-of-care testing devices. Exploration (Beijing). 2023;3(6):20230028.
2022年
1. Fan Z, Wang Y, Li L, et al. Tumor-Homing and Immune-Reprogramming Cellular Nanovesicles for Photoacoustic Imaging-Guided Phototriggered Precise Chemoimmunotherapy [published correction appears in ACS Nano. 2023 Feb 14;17(3):3204.
2. Yang W, Yang G, Li MY, Liu ZY, Liao YH, Liu HY. Photodynamic antitumor activity of Gallium(III) and Phosphorus(V) complexes of trimethoxyl A2B triaryl corrole. Bioorg Chem. 2022;129:106177.
3. Liu C, Wang Y, Li L, et al. Engineered extracellular vesicles and their mimetics for cancer immunotherapy. J Control Release. 2022;349:679-698.
4. Wu Y, Yang R, Wu Q, et al. Trace Analysis of Emerging Virus: An Ultrasensitive ECL-Scan Imaging System for Viral Infectious Disease. ACS Omega. 2022;7(42):37499-37508.
5. Li Z , Teng M , Yang R ,et al.Sb-doped WO3 based QCM humidity sensor with self-recovery ability for real-time monitoring of respiration and wound[J].Sensors and Actuators B: Chemical, 2022, 361:131691.
6. Li Z, Teng M, Jiang Y, et al. YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner. Front Immunol. 2022;13:857727.
