2023年度科研成果

发表论文

1.传染病与生物安全技术方向(22):

Mahmood F, Xu R, Awan MUN, Song Y, Han Q, Xia X, Wei J, Xu J, Peng J, Zhang J. HBV Vaccines: Advances and Development. Vaccines (Basel). 2023 Dec 18;11(12):1862.

Fan Y, Hou Y, Li Q, Dian Z, Wang B, Xia X. RNA virus diversity in rodents. Arch Microbiol. 2023 Dec 1;206(1):9.

Shah T, Hou Y, Jiang J, Shah Z, Wang Y, Li Q, Xu X, Wang Y, Wang B, Xia X. Comparative analysis of the intestinal microbiome in Rattus norvegicus from different geographies. Front Microbiol. 2023 Nov 3;14:1283453.

Zou Y, Yue M, Jia L, Wang Y, Chen H, Zhang A, Xia X, Liu W, Yu R, Yang S, Huang P. Accurate prediction of HCC risk after SVR in patients with hepatitis C cirrhosis based on longitudinal data. BMC Cancer. 2023 Nov 25;23(1):1147.

Ding Y, Gao Y, Chen R, Zhang Z, Li Q, Jia T, Zhang T, Xu R, Shi W, Chen L, Song Y, Han Q, Xia X, Song J, Zhang J. Development of a novel multi-epitope oral DNA vaccine for rabies based on a food-borne microbial vector. Int J Biol Macromol. 2023 Nov 15;255:128085.

Liu L, Li M, Liu G, He J, Liu Y, Chen X, Tu Y, Lin J, Feng Y, Xia X. A novel, highly sensitive, one-tube nested quantitative real-time PCR for Brucella in human blood samples. Microbiol Spectr. 2023 Dec 12;11(6):e0058223.

Liu M, Zhao T, Zhang Y, Zhang AM, Geng J, Xia X. The incidence of hepatocellular carcinoma and clearance of hepatitis B surface for CHB patients in the indeterminate phase: a systematic review and meta-analysis. Front Cell Infect Microbiol. 2023 Sep 12;13:1226755.

Shah T, Wang Y, Wang Y, Li Q, Zhou J, Hou Y, Wang B, Xia X. A Comparative Analysis of the Stomach, Gut, and Lung Microbiomes in Rattus norvegicus. Microorganisms. 2023 Sep 21;11(9):2359.

Zhang Y, Feng Y, Liu Y, Liu L, Xia X, Zhang AM. Genetic polymorphisms in the C19orf66 gene influenced HIV-1 infection in a Yunnan population. PeerJ. 2023 Sep 7;11:e16005.

Zhou H, Xie P, Qiu M, Dong S, Xia X, Yang Z, Yuan Y, Shen L. Arbidol increases the survival rate by mitigating inflammation in suckling mice infected with human coronavirus OC43 virus. J Med Virol. 2023 Sep;95(9):e29052.

Jia Y, Zou X, Yue W, Liu J, Yue M, Liu Y, Liu L, Huang P, Feng Y, Xia X. The distribution of hepatitis C viral genotypes shifted among chronic hepatitis C patients in Yunnan, China, between 2008-2018. Front Cell Infect Microbiol. 2023 Jul 11;13:1092936.

Shah T, Li Q, Wang B, Baloch Z, Xia X. Geographical distribution and pathogenesis of ticks and tick-borne viral diseases. Front Microbiol. 2023 May 24;14:1185829.

Liu N, Liu M, Yang J, Dong S, Yue M, Huang P, Xia X, Zhang AM. Association of genetic polymorphisms in the C19orf66 gene and biochemical indices of HBV infected individuals in Yunnan. Front Cell Infect Microbiol. 2023 May 24;13:1180366.

Mahmood F, Xu R, Awan MUN, Jia T, Zhang T, Shi W, Liu M, Han Q, Zhu Q, Zhang Q, Song Y, Xia X, Zhang J. Transcriptomics based identification of S100A3 as the key anti-hepatitis B virus factor of 16F16. Biomed Pharmacother. 2023 Jul;163:114904.

Qu L, Li X, Huang B, Liu Y, Li Q, Shah T, Ning Y, Li J, Lu Y, Yan L, Wang B, Xia X. Identification and Characterization of Jingmen Tick Virus in Ticks from Yunnan Imported Cattle. Vector Borne Zoonotic Dis. 2023 May;23(5):298-302.

Liu J, Li J, Wang B, Liu Y, Liu L, Liu Y, Feng Y, Qin W, Xia X. Characterization of a newly emerging HCV subtype 6xk among Burmese travelers arriving at Ruili Port in Yunnan, China. J Infect. 2023 Jul;87(1):72-75.

Zhang L, Ye X, Liu Y, Zhang Z, Xia X, Dong S. Research progress on the effect of traditional Chinese medicine on the activation of PRRs-mediated NF-κB signaling pathway to inhibit influenza pneumonia. Front Pharmacol. 2023 Apr 7;14:1132388.

Wu X, Li RF, Lin ZS, Xiao C, Liu B, Mai KL, Zhou HX, Zeng DY, Cheng S, Weng YC, Zhao J, Chen RF, Jiang HM, Chen LP, Deng LZ, Xie PF, Yang WM, Xia XS, Yang ZF. Coinfection with influenza virus and non-typeable Haemophilus influenzae aggregates inflammatory lung injury and alters gut microbiota in COPD mice. Front Microbiol. 2023 Mar 30;14:1137369.

Feng Z, Huang P, Zhang J, Xia X, Zhang AM, Zeng T, Chen Q, Zhu C, Tan W, Zhang Y, Yue M. KIR2DL4/HLA-G polymorphisms were associated with HCV infection susceptibility among Chinese high-risk population. J Med Virol. 2023 Mar;95(3):e28645.

He M, Liu M, Geng J, Liu L, Huang P, Yue M, Xia X, Zhang AM. Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients. Front Cell Infect Microbiol. 2023 Jan 19;13:1119805.

Li Q, Shah T, Wang B, Qu L, Wang R, Hou Y, Baloch Z, Xia X. Cross-species transmission, evolution and zoonotic potential of coronaviruses. Front Cell Infect Microbiol. 2023 Jan 6;12:1081370.

Xu X, Luo Y, He C, Dian Z, Mi H, Yang J, Feng Y, Miao Z, Xia X. Increased Risk of Neurological Disease Following Pediatric Rotavirus Infection: A Two-Center Case-Control Study. J Infect Dis. 2023 May 29;227(11):1313-1321.

2. 环境与职业健康方向(4):

Xu J, Wang J, He Y, Chen R, Meng Q. L.acidophilus participates in intestinal inflammation induced by PM2.5 through affecting the Treg/Th17 balance. Environ Pollut. 2023 Nov 23;341:122977.

Chen Q, Sun M, Cheng H, Qi J, Tan J, Gu Y, Yu T, Li M, Xu H, He Y, Wen W. Inorganic arsenic-mediated upregulation of TUG1 promotes apoptosis in human bronchial epithelial cells by activating the p53 signaling pathway. Toxicol Ind Health. 2023 Dec;39(12):700-711.

Yu J, Li S, Shen S, Zhou Q, Yin J, Zhao R, Tan J, Jiang C, He Y. The transcript NR 134251.1 of lncRNA APTR with an opposite function to all transcripts inhibits proliferation and induces apoptosis by regulating proliferation and apoptosis-related genes. Hum Exp Toxicol. 2023 Jan-Dec;42:9603271221150247.

Sun M, Cheng H, Yu T, Tan J, Li M, Chen Q, Gu Y, Jiang C, Li S, He Y, Wen W. Involvement of a AS3MT/c-Fos/p53 signaling axis in arsenic-induced tumor in human lung cells. Environ Toxicol. 2023 Mar;38(3):615-627.

3. 流行病统计学方向(14):

Zhang M, Li J, Fan J, Feng D, Li Q, Tang S, Li J. Cross-border Activities Associated With Pattern of Amphetamine-type Stimulants Usage Among Drug Users in Southwest of China. Inquiry. 2023 Jan-Dec;60:469580231206608.

Fan L, Liu L, Zhao Y, Mo Y, Li J, Cai L. Trends in the prevalence and economic burden of hypertension and its socioeconomic disparities in rural southwestern China: two repeated cross-sectional studies. BMJ Open. 2023 Nov 17;13(11):e076694.

Du YR, Liu L, Zhao Y, Huang JJ, Golden AR, Cai L. Ethnic disparities in prevalence of chronic non-communicable diseases and its multimorbidity among older adults in rural southwest China. BMC Public Health. 2023 Jun 23;23(1):1217.

Zhao M, Pu X, Ma GY, Zhang MJ, Luo L, Gu RY, Gao MZ, Cai L. Quality of life in patients with cervical cancer between the Han nationality and ethnic minorities in the Yunnan Province of China. BMC Womens Health. 2023 May 3;23(1):217.

Le C, Liu L, Li GH, Zhao Y, Wu X, Rabkin Golden A. Trends in prevalence and clustering of modifiable cardiovascular disease risk factors across socioeconomic spectra in rural southwest China: a cross-sectional study. BMJ Open. 2023 Apr 27;13(4):e071152.

Zhao Y, Li HF, Wu X, Li GH, Golden AR, Cai L. Rural-urban differentials of prevalence and lifestyle determinants of pre-diabetes and diabetes among the elderly in southwest China. BMC Public Health. 2023 Mar 30;23(1):603.

Cai L, Wang XM, Liu L, Zhao Y, Golden AR. Socioeconomic differentials of trends in the prevalence and economic burden of chronic obstructive pulmonary disease in rural southwest China. BMC Public Health. 2023 Jan 20;23(1):141.

Liu M, Yan G, Li Y, You R, Liu L, Zhang D, Yang G, Dong X, Ding Y, Yan S, You D, Li Z. Preoperative splenic area as a prognostic biomarker of early-stage non-small cell lung cancer. Cancer Imaging. 2023 Dec 1;23(1):116.

You D, Wang Y, Xu J, Yang R, Wang W, Wang X, Cao X, Li Y, Yu L, Wang W, Shi Y, Zhang C, Yang H, He Y, Bian L. MiR-3529-3p from PDGF-BB-induced cancer-associated fibroblast-derived exosomes promotes the malignancy of oral squamous cell carcinoma. Discov Oncol. 2023 Sep 5;14(1):166.

Wang WZ, Cao X, Bian L, Gao Y, Yu M, Li YT, Xu JG, Wang YH, Yang HF, You DY, He YW. Analysis of mRNA-miRNA interaction network reveals the role of CAFs-derived exosomes in the immune regulation of oral squamous cell carcinoma. BMC Cancer. 2023 Jun 26;23(1):591.

Luo J, Tang L, Zhang R, Lv M, You D, Yuan Q. Transcriptome-wide profile of 1α,25 dihydroxyvitamin D3 in HTR-8/SVneo cells. J Obstet Gynaecol Res. 2023 Aug;49(8):2093-2101.

Liu W, Luo Z, Zhang L, Wang Y, Yang J, You D, Cao X, Yang W. hsa-mir-(4328, 4422, 548z and -628-5p) in diabetic retinopathy: diagnosis, prediction and linking a new therapeutic target. Acta Diabetol. 2023 Jul;60(7):929-942.

Li C, Zhao K, Zhang D, Pang X, Pu H, Lei M, Fan B, Lv J, You D, Li Z, Zhang T. Prediction models of colorectal cancer prognosis incorporating perioperative longitudinal serum tumor markers: a retrospective longitudinal cohort study. BMC Med. 2023 Feb 21;21(1):63.

Zhang Y, Luo MT, Wu Q, Wang YX, Ma X, Yan G, Zhang SH, Chen Y, Wan N, Zhang L, You D, Wei J, Zhang Z, Zhou TC; Precise-CoVaccine study group. Long-term and effective neutralization against omicron sublineages elicited by four platform COVID-19 vaccines as a booster dose. Cell Discov. 2023 Feb 8;9(1):17.

4. 病原生物学方向(12):

Xu X, Wen S, Zhang Y, Cao W, Yue P, Kong J, Liu M, Fan Y, Chen J, Ji Z, Dong Y, Zhou G, Li B, Liu A, Bao F. A key protein from Borrelia burgdorferi could stimulate cytokines in human microglial cells and inhibitory effects of Cucurbitacin IIa. IBRO Neurosci Rep. 2023 Nov 13;15:376-385.

Ma W, Liu A, Wu X, Gao L, Chen J, Wu H, Liu M, Fan Y, Peng L, Yang J, Kong J, Li B, Ji Z, Dong Y, Luo S, Song J, Bao F. The intricate role of CCL5/CCR5 axis in Alzheimer disease. J Neuropathol Exp Neurol. 2023 Oct 20;82(11):894-900.

Yang J, Kong J, Li B, Ji Z, Liu A, Chen J, Liu M, Fan Y, Peng L, Song J, Wu X, Gao L, Ma W, Dong Y, Luo S, Bao F. Seventy years of evidence on the efficacy and safety of drugs for treating leprosy: a network meta-analysis. J Infect. 2023 Apr;86(4):338-351.

Chen J, Gao L, Wu X, Fan Y, Liu M, Peng L, Song J, Li B, Liu A, Bao F. BCG-induced trained immunity: history, mechanisms and potential applications. J Transl Med. 2023 Feb 10;21(1):106.

Zhang X, Jiang Y, Chen Y, Yang J, Zhang X, Xing L, Liu A, Bao F. Efficacy and safety of antibiotic therapy for post-Lyme disease? A systematic review and network meta-analysis. BMC Infect Dis. 2023 Jan 12;23(1):22.

Wang E, Huang X, Ye Y, Zou S, Chen G, Yang L, Fraser NW, Bao F, Zhou J, Cao X. Persistent inflammation and neuronal loss in the mouse brain induced by a modified form of attenuated herpes simplex virus type I. Virol Sin. 2023 Feb;38(1):108-118.

Wu Y, Ran L, Yang Y, Gao X, Peng M, Liu S, Sun L, Wan J, Wang Y, Yang K, Yin M, Chunyu W. Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota. Life Sci. 2023 Feb 1;314:121312.

Malla P, Wang Z, Brashear A, Yang Z, Lo E, Baird K, Wang C, Cui L. Effectiveness of unsupervised primaquine regimen for preventing Plasmodium vivax malaria relapses in northeast Myanmar, a single-arm non-randomized observational study. J Infect Dis. 2023 Dec 2:jiad552.

Chen X, Tao Z, Liang Y, Ma M, Adah D, Ding W, Chen L, Li X, Dai L, Fanuel S, Zhao S, Hu W, Wu D, Duan Z, Zhou F, Qin L, Chen X, Yang Z. Plasmodium immunotherapy combined with gemcitabine has a synergistic inhibitory effect on tumor growth and metastasis in murine Lewis lung cancer models. Front Oncol. 2023 Oct 17;13:1181176.

Xiang Z, Li D, Wang S, Shen T, He W, Li M, Zeng W, Chen X, Wu Y, Cui L, Yang Z. A simple alkali lysis method for Plasmodium falciparum DNA extraction from filter paper blood samples. Mol Biochem Parasitol. 2023 Jun;254:111557.

Wang X, Bai Y, Xiang Z, Zeng W, Wu Y, Zhao H, Zhao W, Chen X, Duan M, Li X, Zhu W, Sun K, Wu Y, Zhang Y, Li X, Rosenthal BM, Cui L, Yang Z. Genetic diversity of Plasmodium vivax populations from the China-Myanmar border identified by genotyping merozoite surface protein markers. Trop Med Health. 2023 Jan 11;51(1):2.

Duan M, Bai Y, Deng S, Ruan Y, Zeng W, Li X, Wang X, Zhao W, Zhao H, Sun K, Zhu W, Wu Y, Miao J, Kyaw MP, Yang Z, Cui L. Different In Vitro Drug Susceptibility Profile of Plasmodium falciparum Isolates from Two Adjacent Areas of Northeast Myanmar and Molecular Markers for Drug Resistance. Trop Med Infect Dis. 2022 Dec 17;7(12):442.


5. 食品安全方向(14):

Hou Z, Chen Y, Sun Y, Song C, Deng H, Cheng N, Han X, Zhang J, Wang Q, Li Y, Yin J, Meng Q. Sleep Duration and Insomnia with Comorbid Depression and Anxiety Symptoms in Chinese Adults: A Cross-Sectional Study. Nat Sci Sleep. 2023 Dec 21;15:1079-1091.

Xiang Y, Xu H, Chen H, Tang D, Huang Z, Zhang Y, Wang Z, Wang Z, Yangla, Han M, Yin J, Xiao X, Zhao X. Tea consumption and attenuation of biological aging: a longitudinal analysis from two cohort studies. Lancet Reg Health West Pac. 2023 Nov 22;42:100955.

Sun Y, Han X, Hou Z, Deng H, Cheng N, Zhang N, Zhang J, Li Y, Wang Q, Yin J, Meng Q. Association between leisure sedentary behaviour and uterine fibroids in non-menopausal women: a population-based study. BMJ Open. 2023 Nov 28;13(12):e073592.

Zhang T, Li M, Zhao Z, Hong R, Wang X, Yin J. Effective support and care in community: The "Nine to One" comprehensive support mode of people living with Schizophrenia in less-developed multiethnic region of Southwest China. Asian J Psychiatr. 2023 Dec;90:103833.

Guo B, Huang S, Li S, Han X, Lin H, Li Y, Qin Z, Jiang X, Wang Z, Pan Y, Zhang J, Yin J, Zhao X; China Multi-Ethnic Cohort (CMEC) collaborative group. Long-term exposure to ambient PM2.5 and its constituents is associated with MAFLD. JHEP Rep. 2023 Sep 17;5(12):100912.

Li K, Yin J, Qin Z, Ma B, He R, Zhuoma D, Wang Z, Liu Q, Zhao X. Age at menarche and metabolic dysfunction-associated fatty liver disease: Evidence from a large population-based epidemiological study in Southwest China. Prev Med. 2023 Dec;177:107776.

Deng H, Zhang X, Cheng N, Zhang J, Song C, Sun Y, Hou Z, Li Y, Wang Q, Yin J, Meng Q. Asymptomatic hyperuricemia associated with increased risk of nephrolithiasis: a cross-sectional study. BMC Public Health. 2023 Aug 10;23(1):1525.

Qian Y, Che Z, Fu C, Chen X, Zeng J, Zhang X, Zeng Y, Yin J. Study on the Association Between Dietary Quality and Overweight/Obesity of Han Nationality with Cold in Yunnan Plateau by DBI-16 - A Study Based on a Multi-Ethnic Cohort in China. Diabetes Metab Syndr Obes. 2023 Aug 3;16:2311-2327.

Zhao Z, Huang J, Zhong D, Wang Y, Che Z, Xu Y, Hong R, Qian Y, Meng Q, Yin J. Associations of three thermogenic adipokines with metabolic syndrome in obese and non-obese populations from the China plateau: the China Multi-Ethnic Cohort. BMJ Open. 2023 Jul 25;13(7):e066789.

Zhou J, He R, Shen Z, Zhang Y, Gao X, Dejiquzong, Xiao X, Zhang T, Yang D, Wang Y, Song H, Guo Y, Li S, Chen G, Yin J, Zhao X; China Multi-Ethnic Cohort (CMEC) collaborative group. Altitude and metabolic syndrome in China: Beneficial effects of healthy diet and physical activity. J Glob Health. 2023 Jun 30;13:04061.

Zhao Y, Liang X, Wang J, Baima K, Nima Q, Gao Y, Yin J, Liu Q, Zhao X. Association between pregnancy termination history and metabolic syndrome in southwestern Chinese women: modification effect of physical activity. Hum Reprod. 2023 Aug 1;38(8):1560-1570.

Chen J, Zuo H, Wu X, Zhang Y, Tan Q, Yu Z, Laba C, Pan Y, Yin J, Hong F, Zeng P, Zhao X. Diverse associations between adiposity and blood pressure among 80,000 multi-ethnic Chinese adults. BMC Public Health. 2023 Feb 9;23(1):298.

Wu X, Tang W, Tang D, Hu Y, Zhang N, Dai S, Pan Y, Li J, Guan H, Meng J, Zhao X, Xiao X, Yin J. Two a posteriori dietary patterns are associated with risks of hyperuricemia among adults in less-developed multiethnic regions in Southwest China. Nutr Res. 2023 Feb;110:96-107.

Li S, Guo B, Jiang Y, Wang X, Chen L, Wang X, Chen T, Yang L, Silang Y, Hong F, Yin J, Lin H, Zhao X. Long-term Exposure to Ambient PM2.5 and Its Components Associated With Diabetes: Evidence From a Large Population-Based Cohort From China. Diabetes Care. 2023 Jan 1;46(1):111-119.

6. 生物安全防护方向(2):

Cao R, Lei S, Chen H, Ma Y, Dai J, Dong L, Jin X, Yang M, Sun P, Wang Y, Zhang Y, Jia M, Chen M. Using molecular network analysis to understand current HIV-1 transmission characteristics in an inland area of Yunnan, China. Epidemiol Infect. 2023 Jul 18;151:e124.

Chen M, Ma Y, Chen H, Lei S, Jia M. Identification of a new HIV-1 second-generation circulating recombinant form (CRF134_0185) in Yunnan, China. J Infect. 2023 Jul;87(1):e12-e15.


发明专利

1、 陈熙;张家祺;徐士玲;耿劲婷;黄亚铭;黄超;曾炜林;向征;杨照坤, 疟原虫基因诊断引物申请号:CN110331221B  申请日:2019-8-19专利号:ZL 2019 1 0611312.9授权日期2023.5.2

2、 何越峰、蒋成兰、毛一竹、谭婧文、周倩、尹锦瑶、孙明军. 一种抑制DDX17相关RNA表达产物的核苷酸及其应用, 申请号:202110058901.6 申请日:2021-01-17专利号:ZL202110058901.6授权日期2023.5.12

3、 何越峰、谭婧文、周倩、尹锦瑶、孙明军、毛一竹. 一种FBXW7环状RNA的改构体及其在肿瘤药物和新冠疫苗中的应用,申请号:202110058902.0 专利号ZL 202110058902.0授权日期2023.7.21申请日:2021-01-17

4、 何越峰、尹锦瑶、孙明军、毛一竹、蒋成兰、谭婧文、周倩 一种环状RNA载体及其在疫苗中的应用,申请号:202110058897.3 , 专利ZL 2021100588973授权日期2023.7.28申请日:2021-01-17

5、 何越峰、蒋成兰、谭婧文、王萌婕、一种抑制DICER1-AS1表达的siRNA及其应用,申请号:202010189773.4 专利ZL2020101897734 授权日期2023.11.07 申请日期2020.3.18


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