刘建军
学历：生物学博士
专家类别：副教授，硕士研究生导师
邮箱：liujianjun@kmmu.edu.cn
通讯地址：云南省昆明市呈贡区雨花街道春融西路1168号
邮编：650500
简历
教育经历
(1) 2015-09至2021-06，云南大学，遗传学，博士
(2) 2006-09至2009-07，云南大学，细胞生物学，硕士
工作经历
（1）2025-11至 今，昆明医科大学，生物医学工程研究院，副教授
（2）2022-10至2025-10，昆明医科大学，生物医学工程研究院，高级实验师
（3）2019-09至2022-09，昆明医科大学，生物医学工程研究中心，实验师
（4）2009-07至2019-08，昆明医科大学，分子临床医学研究院，助理实验师
研究方向
方向一：代谢相关疾病发病机理及治疗药物研究；
方向二：生殖衰老机制及治疗研究
承担科研项目
（1）云南省科技厅，基础研究计划-重点项目，转录因子EGL-44/TEADs通过调控COMPASS复合体维持脂肪代谢稳态的分子机制，2025-06至2028-05，在研，主持
（2）云南省科技厅，基础研究计划-面上项目，α-酮丁酸通过肠道微生物胆汁酸改善非酒精性脂肪性肝病的机制研究，2024-03至2027-02，在研，主持
（3）国家卫生健康委重点实验室年开放课题，面上项目，COMPASS复合体调控生殖衰老的机制研究，2024-06至2027-05，在研，主持
（4）国家自然科学基金委员会，地区科学基金项目，82160117，α-酮丁酸治疗非酒精性脂肪性肝病的作用及机制，2022-01-01至2025-12-31，已结题，参与
研究成果（论文、专利、专著等）
(1) Jianjun Liu#, Jiayi Sun#, Jiangkun Yu #*, Hang Chen#, Dan Zhang, Tao Zhang, Yicheng Ma, Chenggang Zou, Zhigang Zhang*, Lanqing Ma* and Xue Yu*; Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism, npj Biofilms and Microbiomes,2023,9:29.
(2) Chen Hang#, Huang Minshan#, Zhang Dan, Wang Hui, Wang Da, Li Mengwei, Wang Xianmei, Zhu Rui*, Liu Jianjun* and Ma Lanqin*g. Metformin’s effect on metabolic dysfunction-associated steatotic liver disease through the miR-200a-5p and AMPK/SERCA2b pathway. Frontiers in Pharmacology,2024.
(3) Chunjiao Yu#, Fan Ni#, Mengyao Zheng?, Zhaoda Duan,Wenjie Yang, Man Huang, Hongyan Xu, Mengyu Li ,Shunyu Chen, Chaozhang Gu, Jinhui Yang, Jianjun Liu*, Hongtao Lei* and Shan Yan*. Impact of the prognostic nutritional index on the recompensation of patients with decompensated primary biliary cholangitis. Frontiers in Immunology. 2025.1605380.
(4) Zhang Dan#; Ma Yicheng#; Liu Jian ju#; Wang Da; Geng Zuotao; Wen Daiyan; Chen Hang; Wang Hui; Li Lanyi; Zhu Xiaotong; Wang Xuemin; Huang Minshan; Zou Chenggang*; Chen Yuanli*; Ma Lanqing*; Fenofibrate improves hepatic steatosis, insulin resistance, and shapes the gut microbiome via TFEB-autophagy in NAFLD mice, European Journal of Pharmacology, 2023, 960: 176159.
(5) Wang Da#, Zhang Dan#, Zhu Ziyun, Zhang Yini, Wan Ying, Chen Hang, Liu Jianjun* and Ma Lanqing*. Fagopyrum dibotrys extract improves nonalcoholic fatty liver disease via inhibition of lipogenesis and endoplasmic reticulum stress in high-fat diet-fed mice. BMC Research Notes, 2024, 17:310.
(6) Dan Zhan#g, Yongfang Xu#, Hang Chen#, Da Wang,Zuotao Geng, Yuanli Chen, Yan Chen, Di Xiong, Rongna Yang, Xiaoting Liu, Yuke Zhang, Ping Xiang, Lanqing Ma* and Jianjun Liu*; Fagopyrum dibotrys extract alleviates hepatic steatosis and insulin resistance, and alters autophagy and gut microbiota diversity in mouse models of high-fat diet-induced non-alcoholic fatty liver disease, Frontiers in Nutrition, 2022,9:993501.
(7) Dan Zhang#, Yicheng Ma#, Jianjun Liu#, Yi Deng, Bo Zhou, Yu Wen, Mingke Li,Daiyan Wen, Yunyan Ying, Sufeng Luo, Chunjing Shi, Guangyu Pu, Yinglei Miao, Chenggang Zou, Yuanli Chen* and Lanqing Ma*, Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat DietInduced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy, Frontiers in Pharmacology, 2021,12:689111.
(8) Bi, Y#; Liu, J#; Ma, M; Tao; Peng, Y; Dai, X; Ji, Z; Bai, R; Jian, M; Chen,T; Luo, L; Wang, F; Ding,Z; Liu, A*; Bao, F*; Comparative proteomics profiling revealed the involvement of GRB2-ROCK2 axis in Lyme neuroborreliosis caused by Borrelia Burgdorferi, Journal of cellular and molecular medicine, 2022, 26: 2312-2321.
(9) Luo,Xi#; Yang, Renxiang#; Bai,Yun; Li,Lei; Lin,Na; Sun,Lan; Liu, Jianjun*; Wu, Ze*; Binding of microRNA-135a (miR-135a) to homeobox protein A10 (HOXA10) mRNA in a high progesterone environment modulates the embryonic implantation factors beta3-integrin (ITG beta 3) and empty spiracles homeobox-2(EMX2), Annals of Translational Medicine, 2021,9(8): 662.
(10) Yuan-Li Chen, Yi-Cheng Ma, Jie Tang, Dan Zhang, Qiu Zhao, Jian-Jun Liu, Hong-Shu Tang, Jin-Yu Zhang, Guang-Hui He, Chi-Hui Zhong, Yu-Tong Wu, Heng-Ruo Wen, Lan-Qing Ma*, Cheng-Gang Zou*, Physical exercise attenuates age-related muscle atrophy and exhibits anti-ageing effects via the adiponectin receptor 1 signalling,Journal of Cachexia, Sarcopenia and Muscle 2023,14:1789–1801.
(11) 马岚青; 张丹; 刘建军; 陈媛丽等;代谢相关脂肪性肝病的中西医结合防治关键技术构建及临床应用,云南省人民政府,云南省科技进步二等奖,2025.
(12) 杨荣娜; 殷润; 张雨珂; 熊迪; 陈严; 刘晓婷; 崔琦; “一麦肝通”--金养麦提取物改善非酒精性脂肪性肝病的生物学对话,云南省第十二届“挑战杯”大学生课外学术科技节一等奖.（指导教师:刘建军、张丹）.
(13) 刘建军;张丹;张雨珂;杨荣娜;刘晓婷;熊迪;陈严;陈杭;崔琦;殷润;张家莹;马岚青;一种可调印染标记兼固定小鼠一体化装置,实用新型专利,2022-4-29,中国,专利号ZL 2021 2 2681686.3.
