赵永芳
学历：博士
专家类别：助理研究员
通讯地址：云南省昆明市呈贡区雨花街道春融西路1168号
邮编：650500
简历
教育与工作经历
2023年08月-至今，昆明医科大学，生物医学工程研究院，助理研究员
2019年12月-2022年07月，美国匹兹堡大学，医学院，访问学者
2016年09月-2023年07月，复旦大学，脑科学研究员，博士
2012年09月-2016年06月，南通大学，生命科学学院，学士
研究方向
乳腺癌神经肿瘤学
承担科研项目
1. 国家重点研发计划（No：2017YFC1308403）：远隔缺血适应对慢性脑缺血损伤的免疫调控和血液标记物研究（所属项目：远隔缺血适应对慢性脑缺血损伤的保护作用及转化研究），2017年09月至2021年06月，￥2,000,000 ，结题，参与
2. 国家自然科学基金面上项目（No：81870971）：IL-13介导M1型小胶质细胞死亡促进颅脑外伤后长期功能修复的作用机制，2019年01月至2022年12月，￥560,000 ，结题，参与
研究成果
1. Zhang Y*, Li J*, Zhao Y *，Huang Y, Shi Z, Cao H, Wang C, Wang Y, Gong Y, Yanqin Gao. Arresting the Bad Seed: HDAC3 Regulates Proliferation of Different Microglia after Ischemic Stroke. Science advances.(*co-first author,Revised)
2. Zhang Y*, Zhao Y*, Wang Yn, Li J, Huang Y, Lyv F, Wang Yf, Wei P, Fu Y, Gao Y. 2023. Microglial histone deacetylase 2 is dispensable for functional and histological outcomes in a mouse model of traumatic brain injury. J Cereb Blood Flow Metab. (*co-first author) Accept
3. Zhao Y*, Ma C*, Chen C, Li S, Wang Y, Yang T, Stetler RA, Bennett MVL, Dixon CE, Chen J, Shi Y. 2022. STAT1 contributes to microglial/macrophage inflammation and neurological dysfunction in a mouse model of traumatic brain injury.J Neurosci. JN-RM-0682-22. (* co-first author)
4. Zhao Y*, Mu H*, Huang Y, Li S, Wang Y, Stetler RA, Bennett MVL, Dixon CE, Chen J, Shi Y. 2022. Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury.J Neuroinflammation. 19(1):201. (* co-first author)
5. Pu H*, Ma C*, Zhao Y*, Wang Y, Zhang W, Miao W, Yu F, Hu X, Shi Y, Leak RK, Hitchens TK, Dixon CE, Bennett MV, Chen J. 2021. Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury.J Cereb Blood Flow Metab 41: 2870-86(* co-first author)
6. Han W, Pu H, Li S, Liu Y, Zhao Y, Xu M, Chen C, Wu Y, Yang T, Ye Q, Wang H. 2023. Targeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia/macrophages and promotes long-term recovery after ischemic stroke.Journal of Neuroinflammation. 20(1):178.
7. Liu Y, Li S, Wang R, Pu H, Zhao Y, Ye Q, Shi Y. 2021. Inhibition of TGFβ-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice.Neurobiol Dis 151: 105257
8. Miao W, Zhao Y, Huang Y, Chen D, Luo C, Su W, Gao Y. 2020. IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury.J Immunol 204: 1486-98
9. Zhang J, Zhang W, Gao X, Zhao Y, Chen D, Xu N, Pu H, Stetler RA, Gao Y. 2019. Preconditioning with partial caloric restriction confers long-term protection against grey and white matter injury after transient focal ischemia.J Cereb Blood Flow Metab 39: 1394-409
10. Mu H, Gao X, Li S, Wei P, Zhao Y, Zhang W, Wang Y, Gao Y. 2019. Distinctive functional deficiencies in axonal conduction associated with two forms of cerebral white matter injury.CNS Neurosci Ther 25: 1018-29
11. Mao L, Yang T, Li X, Lei X, Sun Y, Zhao Y, Zhang W, Gao Y, Sun B, Zhang F. 2019. Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway.J Cereb Blood Flow Metab 39: 352-66
