姓名:戴学勤
学历:博士
专家类别:副教授,硕士生导师,云南省“兴滇英才支持计划”青年人才,云南省派驻企业科技特派员
电话:18687199539
邮箱:daixueqin@kmmu.edu.cn
通讯地址:云南省昆明市呈贡区雨花街道春融西路1168号
邮编:650500
简历
2025年10月-至今,昆明医科大学,生物医学工程研究院,副教授
2023年2月-2025年10月,昆明医科大学,生物医学工程研究院,讲师
2017年9月-2023年1月,中国科学院昆明动物研究所,硕博连读,理学博士
2013年9月-2017年9月,云南师范大学,生命科学学院,理学学士
研究方向
肿瘤生物学;基因组不稳定;乳腺(癌)类器官应用于病人精准用药指导的应用研究。
招生专业为病理学与病理生理学,欢迎对乳腺癌感兴趣的学生报考,要求对科研有兴趣,有自学能力,为人踏实,心态积极。
承担科研项目
(1)国家自然科学基金委员会,青年科学基金项目,82302957,小细胞肺癌ARID1A功能丢失与靶向PARP1的协同致死效应及机制研究,2024-01-01至2026-12-31,30万,在研,主持。
(2)云南省科技厅基础研究计划,面上项目,202401CF070054,微纳塑料促进乳腺癌转移的小鼠模型研究,2024-06-01至2027-05-31,10万,在研,主持。
(3)云南省科技厅基础研究计划,面上项目,202501AT070101,微纳塑料促进乳腺癌转移的小鼠模型研究,2025-06-01至2028-05-31,10万,在研,主持。
(4)云南省科技厅科技成果转化专项,2025年昆明医科大学戴学勤企业科技特派员,2025-11-01至2028-10-31,2万,在研,主持。
(5)国家自然科学基金委员会,重点项目,E3泛素连接酶BCA2调控乳腺发育和促乳腺癌进展的功能和机制研究及靶向策略探索,2025-01-01至2029-12-31,230万,在研,参与。
(6)云南省重大科技计划生物医药专项,202302AA310046,乳腺癌类器官库及靶向示踪诊疗技术平台建设和运用,2023-06至2026-05,2270万元,在研,子课题二项目执行负责人。
(7)云南省卫健委,临床医学中心项目,2024YNLCYXZX0419,乳腺癌类器官指导病人精准用药研究,2025-01-01至2027-12-31,50万,在研,项目执行负责人。
研究成果(论文、专利、专著等)
1. Dai X, Wang X, Yang C, Huang M, Zhou Z, Qu Y, Cui X, Liu R#, and Chen C#. 2022. Human fibroblasts facilitate the generation of iPSCs-derived mammary-like organoids.Stem Cell Research & Therapy[J]. 13, 377. (IF-5y: 8.387)
2. Dai X, and Guo X#. 2021. Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations.Ageing Research Reviews[J]. 68, 101342. (IF-5y: 14.282)
3. Qiu B#*,Dai X*, Li P, Larsen R, Li R, Price A, Ding G, Texada M, Zhang X, and Zuo D, Gao Q, Jiang W, Wen T, Pontieri L, Guo C, Rewitz K, Li Q, Liu W, Boomsma J#, Zhang G#. 2022. Canalized gene expression during development mediates caste differentiation in ants.Nature Ecology & Evolution[J]. 6, 1753-1765. (IF-5y: 18.635)
4. Li, R*,Dai, X*, Zheng, J., Larsen, R. S., Qi, Y., Zhang, X., ... & Zhang, G#. 2024. Juvenile hormone as a key regulator for asymmetric caste differentiation in ants.Proceedings of the National Academy of Sciences, 121(46), e2406999121. (IF-5y: 9.58)
5. Yu Zhu*, Zhibi Zhang*,Xueqin Dai*, Wenjing Liu, Jian Sun, Jialing Liu, Yuxin Zhao, Wenlong Ren, Chenglong Pan, Zhongmei Zhou, Ying Yan, Longlong Zhang, Ceshi Chen. DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targeting IMPDH2 to inhibit triple-negative breast cancer.Acta Pharmaceutica Sinica B, 2025. (IF-5y: 14.6)
6. Cao, Guozhen*, Liying Ma*, Xueqin Dai*, Peng Hou*, Xinhuang Yao, Gongfeng Li, Jiahui Zhang, Ceshi Chen*, and Wenchu Lin*. "ARID1A Governs Genomic Stability and Proliferation in SCLC via c-MYC/PARP1 Suppression Driving Vulnerability to BET Inhibitors."Research, (2025): 0908. (IF-5y: 10.9)
7. Guo X*,Dai X*, Ni J, Ma X, Xue J, and Wang X#. 2019. Geraniin Differentially Modulates Chromosome Stability of Colon Cancer and Noncancerous Cells by Oppositely Regulating their Spindle Assembly Checkpoint.Environmental and Molecular Mutagenesis[J]. 60, 254-268. (IF-5y: 3.892)
8. Guo X*,Dai X*, Wu X, Zhou T, Ni J, Xue J, and Wang X#. 2020a. Understanding the birth of rupture-prone and irreparable micronuclei.Chromosoma[J]. 129, 181-200. (IF-5y: 4.316)
9. Guo X*,Dai X*, Zhou T, Wang H, Ni J, Xue J, and Wang X. 2020b. Mosaic loss of human Y chromosome: what, how and why. Human Genetics[J]. 139, 421-446. (IF-5y: 6.099)
10. Guo, X, &Dai, X. 2024. A complex systems approach to mosaic loss of the Y chromosome. GeroScience, 1-21. (IF-5y: 5.3)
11. Joel Vizueta*. Zijun Xiong*. Guo Ding*. Rasmus S. Larsen. Hao Ran. Qionghua. Josefin Stiller. Wei Dai. Wei Jiang. Jie Zhao. Chunxue Guo. Xiafang Zhang. Dashuang Zuo. Wenjiang Zhong. Morten Schi?tt. Chengyuan Liu. Hailin Zhang.Xueqin Dai. Ignasi Andreu. Yue Shi1. Sandra Tretter. Ding He. Shubham Gautam. Zelin Li. Glenn Hickey. Aniek B.F. Ivens. Marie-Pierre Meurville. Francisco Hita-Garcia. Jamie M. Kass. Benoit Guénard. Corrie Moreau. Benedict Paten. Adria C. LeBoeuf. Evan P. Economo. GAGA Consortium. Michel Chapuisat. Jonathan Z. Shik. Philip S. Ward. Jürgen Heinze? Ted R. Schultz. Qiye Li. Robert R. Dunn. Nathan J. Sanders. Weiwei Liu*. Lukas Schrader*. Jacobus J. Boomsma1*. Guojie Zhang*. Adaptive radiation and social evolution of the ants.Cell (2025). (IF-5y: 42.5)
12. Li Q*, Wang M*, Zhang P*, Liu Y*, Guo Q, Zhu Y, Wen T,Dai X, Zhang X, Nagel M, Dethlefsen BH, Xie N, Zhao J, Jiang W, Han L, Wu L, Zhong W, Wang Z, Wei X, Dai W, Liu L, Xu X, Lu H, Yang H, Wang J, Boomsma JJ, Liu C#, Zhang G#, and Liu W# 2022. A single-cell transcriptomic atlas tracking the neural basis of division of labour in an ant superorganism. Nature Ecology & Evolution[J]. 6, 1191-1204. (IF-5y: 18.635)
13. Guo, Y*, Li, Y, Zhou, Z, Hou, L, Liu, W, Ren, W, Mi D, Sun J,Dai X, Wu Y, Cheng Z, Wu T, Luo Q, Tian C, Li F#, Yu Z#, Chen Y# & Chen, C#. 2024. Targeting PRMT5 through PROTAC for the treatment of triple-negative breast cancer. Journal of Experimental & Clinical Cancer Research, 43(1), 314. (IF-5y: 18.635) (IF-5y: 11.4)
Wang Y*, Zhang C*, Wang N*, Li Z*, Heller R*, Liu R*, Zhao Y*, Han J*, Pan X, Zheng Z,Dai X, Chen C, Dou M, Peng S, Chen X, Liu J, Li M, Wang K, Liu C, Lin Z, Chen L, Hao F, Zhu W, Song C, Zhao C, Zheng C, Wang J, Hu S, Li C, Yang H, Jiang L, Li G, Liu M, Sonstegard TS, Zhang G, Jiang Y#, Wang W#, and Qiu Q#. 2019. Genetic basis of ruminant headgear and rapid antler regeneration.Science[J]. 364, eaav6335. (IF-5y: 59.937)