一、个人简介
严慧，博士，研究员，博士生导师。司法鉴定科学研究院法医毒物法化研究室副主任/研究员，主持和参与国家和省部级科研项目10余项，主持和参与制定毒物毒品鉴定技术国家标准、行业标准20余项，在国内外有影响力的专业期刊上发表论文80余篇,参与撰写《法医毒物学手册》等多部专著，被《法医学杂志》《Forensic science research》等多家杂志聘为专家审稿人、专业编辑，曾获司法部司法为民好榜样称号，上海市科技进步奖一等奖、二等奖、三等奖。
二、主要研究方向
从事法医毒物学教学培训、科学研究及司法鉴定工作，主要研究方向：（1）体内毒物及代谢物分析；（2）新型毒品体内外代谢研究；（3）毒物中毒机制的代谢组学研究。
三、近五年主要承担的科研项目
（1）国家重点研发计划子课题，新精神活性物质筛选数据库构建及预警系统组建研究，2022.10-2025.9，主持。
（2）国家重点研发计划课题，环境及生物样本中新精神活性物质高通量鉴测与精准预判技术研究，2025.5-2028.4，主持。
四、近五年代表性成果
[1] Zhenshuo Guo, Yiling Tang, Ruilin Zhang, Yu Ma, Ruxin Luo, Ping Xiang, Hui Yan*, Wenjia Duan*. Generation and distribution of cyanide in rats and humans following sodium cyanoborohydride exposure [J]. Toxicology and Applied Pharmacology, 2025, 505: 117592.（IF=3.4）
[2] Yu Liu, Xinze Liu, Zhenshuo Guo, Ping Xiang, Hui Yan*. Development and validation of a LC–MS/MS method for the detection of 38 benzodiazepines and 2 Z-drugs in blood [J]. Journal of Chromatography B, 2025, 1266: 124772.（IF=2.8）
[3] Xiaoyu Qian, Liying Zhou, Xin Wang, Huosheng Qiang, Jian Li, Ping Xiang, Hui Yan*. Rapid qualitative and quantitative analysis of etomidate and its structuralanalogs in blood by UPLC-MSMS and application in six forensic cases [J]. Journal of Pharmaceutical and Biomedical Analysis, 2025, 264: 116962.（IF=3.1）
[4] Lina Zhong, Longjie Li, Qingfeng He, Xiao Zhu, Ping Xiang, Xiaoqiang Xiang*, Hui Yan*. Rat-to-human PBPK model of U-47700: Unveiling pharmacokinetic risks of a synthetic opioid through interspecies extrapolation [J]. Toxicology and Applied Pharmacology, 2025, 499: 117352.（IF=3.4）
[5] Jinxiao Zhai#, Hui Yan#, Minghao Liu, Chen Jiang, Mingyang Jin, Bing Xie, Chunling Ma, Bin Cong*, Di Wen*. Decoding gelsenicine-induced neurotoxicity in mice via metabolomics and network toxicology [J]. Phytomedicine, 2025, 142: 156753.（IF=8.6）
[6] Yiling Tang, Linhao Xu, Zhenshuo Guo, Junbo Zhao, Yue Xiao, Ping Xiang, Lili Xu, Hui Yan*. Metabolism study of two phenethylamine ? derived new psychoactive substances using in silico, in vivo, and in vitro approaches [J]. Archives of Toxicology, 2025, 99(6): 2367–2378.（IF=6.9）
[7] Yiling Tang#, Linhao Xu#, Junbo Zhao, Xiaoyu Qian, Huosheng Qiang, Ping Xiang, Hui Yan*. Metabolic profile of Etomidate and Its Three Analogs in Zebrafish, Human Liver Microsomes, Human Urine and Hair Samples using UHPLC-Q Exactive Orbitrap-HRMS [J]. Drug Testing and Analysis, 2025, 17(9): 1662–1674.（IF=2.7）
[8] Zixuan Song, Zhenshuo Guo, Yiling Tang, Miao Zhang, Ping Xiang, Wei Liu*, Hui Yan*. Qualitative confirmation of 30 phencyclidine analogs in human blood and urine using GC-HRMS and a self-built library search [J]. Journal of Chromatography B, 2025, 1252: 124464.（IF=2.8）
[9] Liying Zhou, Junbo Zhao, Wanting Xie, Ping Xiang, Yan Shi, Hejian Wu, Hui Yan*. Detection of "smoke powder" etomidate and its metabolite etomidate acid in blood and urine by UHPLC-MS/MS: Application in authentic cases [J]. Journal of Analytical Toxicology, 2024, 48(9): 701-709.（IF=2.6）
[10] JiaoJiao Ji, Jiaman Lin, Xin Wang, Hang Chen, Qiran Sun, Duoqi Xu, Ping Xiang, Junling Dun, Hui Yan*, Min Shen*. Estimation of the time of zolpidem intake and differentiation between consumption and external contamination using MALDI-MSI for investigations on single hair samples [J]. Journal of Pharmaceutical and Biomedical Analysis, 2024, 248: 116272.（IF=3.1）
五、联系方式
yanh501@163.com
