一、个人简介
严慧，博士，研究员，硕士生导师。司法鉴定科学研究院法医毒物法化研究室副主任/研究员，主持和参与国家和省部级科研项目10余项，主持和参与制定毒物毒品鉴定技术国家标准、行业标准20余项，在国内外有影响力的专业期刊上发表论文80余篇,参与撰写《法医毒物学手册》等多部专著，被《法医学杂志》《Forensic science research》等多家杂志聘为专家审稿人、专业编辑，曾获司法部司法为民好榜样称号，上海市科技进步一等奖、三等奖。
二、主要研究方向
从事法医毒物学教学培训、科学研究及司法鉴定工作，主要研究方向：（1）体内毒物及代谢物分析；（2）新型毒品体内外代谢研究；（3）毒物中毒机制的代谢组学研究。
三、近五年主要承担的科研项目
（1）国家重点研发计划子课题，新精神活性物质筛选数据库构建及预警系统组建研究，2022.10-2025.9,主持
（2）上海市自然科学基金项目，新型毒品5-MeO-DiPT的体内代谢和作用机制研究，2019.7-2022.6，主持
（3）上海市人才发展基金，2020.1-2021.12，主持
四、近五年代表性成果
[1]Jiao-Jiao Ji, Jiaman Lin, Xin Wang, Hang Chen, Qiran Sun, Duoqi Xu, Ping Xiang,Junling Dun, Hui Yan*, Min Shen*.Estimation of the time of zolpidem intake and differentiation between consumption and external contamination using MALDI-MSI for investigations on single hair samples.Journal of Pharmaceutical and Biomedical Analysis.2024,248: 116272.（IF=3.1）
[2]Yiling Tang, Linhao Xu, Junbo Zhao, Ping Xiang, Hui Yan*.Metabolism of dipentylone in zebrafish and human liver microsomes determined by liquid chromatography–high resolution mass spectrometry.Journal of Pharmaceutical and Biomedical Analysis. 2023,236:115710. （IF=3.1）
[3]Mobing Chen, Wei Liu, Ping Xiang, Linhao Xu, Yiling Tang, Ran Kong, Shuo Yang, Hui Yan*,Bin Di.Development of an LC-MS/MS method for the determination of multiple mycotoxins in human Urine.Food Additives & Contaminants: Part A.2023,40(7):917-927. （IF=2.3）
[4]Linhao Xu,Xinze Liu,Zixuan Song,Ping Xiang,Taijun Hang,Hui Yan*.In vitro and in vivo metabolism of 3-Methoxyeticyclidine inhuman liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography–high-resolution mass spectrometry.Drug Testing and Analysis. 2023;1–8.DOI: 10.1002/dta.3488. （IF=2.6）
[5]Caixia Guo#,Hui Yan#, Wei Liu,Ping Xiang,Bin Di,Min Shen.Liquid chromatography with tandem mass spectrometric method for determination of 425 drugs and poisons in dried blood spots and application to forensic cases.Forensic Toxicology,2023, https://doi.org/10.1007/s11419-023-00659-9. （IF=2.8）
[6]Xinze Liu, Wei Liu, Ping Xiang, Taijun Hang, Yan Shi, Linna Yue, and Hui Yan*. Metabolism of ADB-4en-PINACA in Zebrafish and Rat Liver Microsomes Determined by Liquid Chromatography–High Resolution Mass Spectrometry.Journal of Analytical Chemistry, 2022,77(8):1036–1046.（IF=1.0）
[7] Mobing Chen, Xinze Liu, Shuo Yang, Zhuonan Chen, Bin Di, Wei Liu*, Hui Yan*.HPLC–MS/MS method for the simultaneous determination of aflatoxins in blood: toxicokinetics of aflatoxin B 1 and aflatoxin M 1 in rats. Journal of Analytical Science and Technology.2022,13:27-37.（IF=2.5）
[8]Kai Zhang#, Hui Yan#, Ruina Liu, Ping Xiang, Kaifei Deng, Ji Zhang, Ya Tuo, Zhenyuan Wan*, Ping Huang*. Exploring metabolic alterations associated with death from asphyxia and the differentiation of asphyxia from sudden cardiac death by GC-HRMS-based untargeted metabolomics. Journal of Chromatography B, doi:10.1016/j.jchromb.2021.122638（IF=2.8）
[9]Yue Linna, Xiang Ping, Shen Baohua, Xu Duoqi, Song Fenyun, Yan Hui*. Metabolism of 4F-MDMB-BICA in zebrafish by liquid chromatography-high resolution mass spectrometry. Drug Testing and Analysis.2021,13:1223-1229.（IF=2.6）
[10]Zhang Kai#, Yan Hui#, Liu Ruina, Xiang Ping, Zhang Ji, Deng Kaifei,Huang Ping*, Wang Zhenyuan*.The Use of Gas Chromatography Coupled with High-Resolution Mass Spectrometry-Based Untargeted Metabolomics to Discover Metabolic Changes and Help in the Determination of Complex Causes of Death: A Preliminary Study.ACS Omega,2021,6(3):2100-2109.（IF=3.7）
五、联系邮箱: yanh@ssfjd.cn
