周靖娥
学历：博士
专家类别：助理研究员，硕士生导师
邮箱：zhoujinge@kmmu.edu.cn
通讯地址：云南省昆明市呈贡区雨花街道春融西路1168号
邮编：650500
简历
2010.09-2014.06中国药科大学 药物制剂 本科；
2014.09-2017.06华东师范大学 药理学 硕士；
2019.09-2022.12华东师范大学 生物化学与分子生物学 博士；
2023.03-至今 昆明医科大学 生物医学工程研究院 助理研究员；
研究方向
1. 脂质纳米颗粒（LNP）递药系统，重点研究针对肿瘤、肝、肺纤维化等疾病；
2. 核酸药物siRNA、mRNA、DNA的体内靶向递送；
3. CAR-T免疫疗法，CAR-Macrophage疗法。
研究成果（论文、专利、专著等）
1. Jing-e Zhou#, Lei Sun#, Yujie Jia, Zhehao Wang, Tengshuo Luo, Jingwen Tan, Xiaoyan Fang, Hongjia Zhu, Jing Wang, Lei Yu*, Zhiqiang Yan*, Lipid nanoparticles produce chimeric antigen receptor T cells with interleukin-6 knockdown in vivo. J Control Release 2022, 350:298-307.
2. Jing-E Zhou#, L. S#, Li Liu, Yujie Jia, Yuqiao Han, Jiaqi Shao, Jing Wang, Yiting Wang, Lei Yu, Zhiqiang Yan Hepatic macrophage targeted siRNA lipid nanoparticles treat non-alcoholic steatohepatitis. J Control Release 2022, 343, 175-186.
3. Zhou, J. E.; Yu, J.; Wang, Y.; Wang, H.; Wang, J.; Wang, Y.; Yu, L.; Yan, Z., ShRNA-mediated silencing of PD-1 augments the efficacy of chimeric antigen receptor T cells on subcutaneous prostate and leukemia xenograft. Biomed Pharmacother 2021, 137, 111339.
4. Lei Sun#,Jinge. Zhou#, Tengshuo Luo#, Jing Wang, Liqing Kang, Yeying Wang, Shenggen Luo, Zhehao Wang, Ziyu Zhou, Jiaxi Zhu, Jiahui Yu, Lei Yu, and Zhiqiang Yan*, Nanoengineered Neutrophils as a Cellular Sonosensitizer for Visual Sonodynamic Therapy of Malignant Tumors. Advanced Materials 2022, 34 (15).
5. Yeying Wang, Y. L., Jing-e Zhou, Lizhou Lin, Chao Jia, Jing Wang, Lei Yu, Yiting Wang*, Zhiqiang Yan*, Controllable hydrogen release for gas-assisted chemotherapy and ultrasonic imaging of drug-resistant tumors. Chemical Engineering Journal 2021, 421.
6. Hongjia Zhu, Xiaoyan Fang, Israth Jahan Tuhin, Jingwen Tan, Jing Ye, Yujie Jia, Nan Xu. Liqing Kang, Minghao Li, XiaoYan Lou,Jing-e Zhou, Yiting Wang, Zhiqiang Yan, Lei Yu, CAR T cells equipped with a fully human scFv targeting Trop2 can be used to treat pancreatic cancer. Journal of Cancer Research and Clinical Oncology 2022, 148, 2261-2274.
7. Kai Huang, S. W, Wenshuo Wang, Jing-e Zhou, Jiechun Huang, Fangrui Wang, Liewen Pang, Yiqing Wang*, Xiaotian Sun*, Erythrocyte membrane coated nanoparticle-based control releasing hydrogen sulfide system protects ischemic myocardium. Nanomedicine 2021, 16 (6), 465-480.
8. Yeying Wang, Jian Chen, Qilong Li, Ji Li,Jing-e Zhou, Jing Wang, Zhiqiang Liang, Jingwen Tan, Lei Yu, Minghao Li, Yiting Wang, Nan Xu, Feng Qu, Zhiqiang Yan, A Photopolymerized Semi-Interpenetrating Polymer Networks-Based Hydrogel Incorporated with Nanoparticle for Local Chemotherapy of Tumors. Pharm Res 2021, 38, 669-680.
9. 王哲豪，周靖娥，王镜*，微流控技术用于制备稳定核酸脂质纳米粒(SNALP)，实验技术与管理，2022,039(007) - 57～62.
专利：
1. 闫志强，周靖娥，王哲豪，孙磊，王镜，俞磊：一种用于体内产生CAR-M的脂质纳米颗粒及其制备方法和应用，2022-04-08，中国，CN202210366023.9
2. 闫志强，周靖娥，俞磊；一种用于体内自组装CAR-T的纳米递送系统及其制备方法和应用, 2022-03-04,中国，CN114129718A
3. 王镜，王哲豪，周靖娥，骆声根，闫志强，孙磊，王烨颖，罗腾硕，丁楠津；一种利用新型微流控装置制备核酸脂质纳米粒的方法，2021-12-28，中国，CN113842960A
4. 闫志强，孙磊，周靖娥，罗腾硕，王镜，骆声根，王哲豪，王烨颖，丁楠津；一种工程化改造的中性粒细胞声敏剂药物递送系统及其应用，2021-11-09，中国，CN113616790A
