个人简历：
严慧，女，博士, 副研究员，硕士生导师。2008年进入司法鉴定科学研究院从事法医毒物学研究工作，现为法医毒物法化研究室副研究员、副主任法医师，主持和参与多项国家级和省部级科研项目，主持和参与制定多项毒物毒品鉴定技术国家标准、行业标准，在国内外有影响力的专业期刊上发表科技论文50余篇,参与撰写《法医毒物学手册》等多部专著，被《法医学杂志》《Forensic science research》等多家杂志聘为专家审稿人、专业编辑。
主要研究方向：
法医毒物和毒理学，主要从事体内毒物毒品分析及代谢组学研究。
主要承担科研项目：
1. 上海市自然科学基金项目，新型毒品5-MeO-DiPT的体内代谢和作用机制研究，2019.7-2022.6，主持
2. 上海市人才发展基金，2020.1-2021.12，主持
3. 国家自然科学基金青年项目，基于质谱的代谢组学方法研究溴敌隆的血液毒性及其作用机制，2014.1-2016.12，主持
4. 上海市自然科学基金项目,溴敌隆和大隆中毒生物标志物研究,2013.7-2016.6，主持。
代表性学术成果：
1. Hui Yan, Ping Xiang, Min Shen. Current status of hair analysis in forensic toxicology in China. Forensic Sciences Research, 2021, DOI: 10.1080/20961790.2021.1921945
2. Kai Zhang#, Hui Yan#, Ruina Liu, Ping Xiang, Kaifei Deng, Ji Zhang, Ya Tuo, Zhenyuan Wan*, Ping Huang*. Exploring metabolic alterations associated with death from asphyxia and the differentiation of asphyxia from sudden cardiac death by GC-HRMS-based untargeted metabolomics. Journal of Chromatography B, doi:10.1016/j.jchromb.2021.122638
3. Yue Linna, Xiang Ping, Shen Baohua, Xu Duoqi, Song Fenyun, Yan Hui*. Metabolism of 4F-MDMB-BICA in zebrafish by liquid chromatography-high resolution mass spectrometry. Drug Testing and Analysis. 2021.doi: 10.1002/dta.3019
4. Zhang Kai#, Yan Hui#, Liu Ruina, Xiang Ping, Zhang Ji, Deng Kaifei, Huang Ping*, Wang Zhenyuan*. The Use of Gas Chromatography Coupled with High-Resolution Mass Spectrometry-Based Untargeted Metabolomics to Discover Metabolic Changes and Help in the Determination of Complex Causes of Death: A Preliminary Study. ACS Omega, 2021,6(3):2100-2109.
5. Jiao-Jiao Ji, Hui Yan, Ping Xiang, Xin Wang, Min Shen. The Distribution of?Quetiapine and 7-Hydroxyquetiapine in?Guinea Pig?Hair Roots?and Shafts after Repeated Administration: Exploration of the Mechanism of Drug Entry and Retention in?Hair. Journal of analytical toxicology, 2020：bkaa151 doi: 10.1093/jat/bkaa151
6. Hui Yan, Jiao-jiao Ji, Ping Xiang, Min Shen. Characteristics of quetiapine and 7-hydroxyquetiapine in hair roots and blood after a single dose of quetiapine. Forensic Science International. 309 (2020) doi: 10.1016/j.forsciint.2020.110189. Epub 2020 Feb 12.
7. Xiuying Yan, Shuai Yuan, Zhiguo Yu, Yunli Zhao, Sujing Zhang, Hejian Wu, Hui Yan*, Ping Xiang*. Development of an LC-MS/MS method for determining 5-MeO-DIPT in dried urine spots and application to forensic cases. Journal of Forensic and Legal Medicine, 72 (2020) doi: 10.1016/j.jflm.2020.101963. Epub 2020 Apr 12.
8. Xiuying Yan, Ping Xiang, Yunli Zhao, Zhiguo Yu*, Hui Yan **. Determination of 5-MeO-DIPT in human urine using gas chromatography coupled with high resolution Orbitrap mass spectrometry. Journal of Analytical Toxicology.
9. Ji Jiao-jiao, Yan Hui, Xiang Ping, Shen Baohua, Shen Min*.An LC–MS/MS method for the simultaneous determination of 12 psychotropic drugs and metabolites in hair: Identification of acute quetiapine poisoning using hair root. Forensic Science International 301 (2019) 341–349.
10. Meiru Pan, Ping Xiang, Zhiguo Yu, Yunli Zhao*, Hui Yan*. Development of a high-throughput screening analysis for 288 drugs and poisons in human blood using Orbitrap technology with gas chromatography-high resolution accurate mass spectrometry. Journal of Chromatography A 2019, 1587: 209-226.
11. Zheng Qiao, Ping Xiang, Baohua Shen, Min Shen, Hui Yan*. Simultaneous Determination of 13 Anticoagulant Rodenticidesin Human Blood by Liquid Chromatography–Tandem Mass Spectrometry and its Application in Three Poisoning Cases. Journal of Forensic Sciences, 2018, 63(3): 784-792.
12. Chen Lizhu, Shen Baohua, Wang Songtao, Yu Yingjia, Yan Hui, Shi Yan, Duan Gengli*, Xiang Ping*. Pharmacokinetics of selegiline, R-methamphetamine, R-amphetamine and desmethylselegiline in oral fluid after a single oral administration of selegiline. Drug Testing and Analysis, 2019-1-6, doi: 10.1002/dta.2568.
13. Hui Yan, Hang Chen, Zhengdong Li, Min Shen, Xianyi Zhuo, Hejian Wu, Ping Xiang. Phosphine Analysis in Postmortem Specimens Following Inhalation of Phosphine: Fatal Aluminum Phosphide Poisoning in Children. Journal of Analytical Toxicology, 2018, 42(5): 330-336.
14. Hui Yan, Ping Xiang, Jingshuo Zhang,Liqi Xie, Min Shen*. Dynamic changes of serum protein in rats with acute intoxication of Chinese cobra snake venom by proteomic analysis. Forensic Sciences Research, DOI: 10.1080/20961790.2017.1405565.
15. Hui Yan, Ping Xiang, Sujing Zhang, Baohua Shen*, Min Shen*. Diagnosis of aluminum phosphide poisoning using a new analytical approach: forensic application to a lethal intoxication. International Journal of Legal Medicine, 2017, 131: 1001–1007
16. 岳琳娜，严慧，向平，刘伟，宋粉云. 液相色谱-四极杆/静电场轨道阱高分辨质谱鉴定一种新精神活性物质5F-MDMB-PICA在斑马鱼体内的代谢产物.分析测试学报, 2021, 40(5): 690-698.
17. 严慧，史格非，沈敏. 基于SCIE收录的中国大陆地区法医毒物学文献计量学分析.法医学杂志, 2019, 35(6): 667-676.
18. 严慧，史格非，沈敏*. 基于文献计量学指标的法医毒物学研究状况分析.中国司法鉴定,2019(4)：29-37.
19. 严慧，沈保华，向平，乔正，吴何坚，沈敏*.基于 GC-MS 的溴鼠灵毒性代谢组学研究.中国法医学杂志, 2018, 33(6): 573-577.
20. 严慧，卓先义，沈保华，向平，沈敏*. 基于HPLC-TOF-MS代谢组学方法的溴鼠灵毒性作用评价. 法医学杂志, 2017, 33(3): 247-251.
联系邮箱: yanh@ssfjd.cn
